West Nile virus – eu “case” definice, 2018
3.53. WEST NILE VIRUS INFECTION (WNV)
Clinical Criteria
At least one of the following three:
- Any person with fever
- Encephalitis
- Meningitis
Laboratory Criteria
Laboratory test for case confirmation
At least one of the following four:
- Isolation of WNV from blood or CSF
- Detection of WNV nucleic acid in blood or CSF
- WNV specific antibody response (IgM) in CSF
- WNV IgM high titre AND detection of WNV IgG, AND confirmation by neutralisation
Laboratory test for a probable case
WNV specific antibody response in serum
Laboratory results need to be interpreted according to flavivirus vaccination status
Epidemiological Criteria
At least one of the following two epidemiological links:
- Animal to human transmission (residing, having visited or having been exposed to mosquito bites in an area where WNV is endemic in horses or birds)
- Human to human transmission (vertical transmission, blood transfusion, transplants)
Case Classification
A.Possible case NA
B.Probable case
Any person meeting the clinical criteria AND with at least one of the following two:
- an epidemiological link
- a laboratory test for a probable case
C.Confirmed case
Any person meeting the laboratory criteria for case confirmation
Note: Serological results should be interpreted according to previous exposure to other flaviviral infections and the flavivirus vaccination status. Confirmed cases in such situations should be validated by serum neutralization assay or other equivalent assays.
Zdroj: Prováděcí rozhodnutí Komise (EU) 2018/945 ze dne 22. června 2018 o přenosných nemocích a souvisejících zvláštních zdravotních problémech, které musí být podchyceny epidemiologickým dozorem, a o příslušných definicích případů (https://eur-lex.europa.eu/eli/dec_impl/2018/945/oj )